In analyzing seismic behaviour of highway bridges constructed on soft soil deposits, it is important to take account of soil-structure interaction effects. In this paper, seismic response of a bridge pier-foundation is investigated based on earthquake acceleration records measured simultaneously on the pier crest and on the ground surface near that bridge. Four motions were used in the analysis, i.e., two were induced by two earthquakes with magnitudes of 7.5 and 6.6, respectively; and two by their aftershocks. In the former two earthquakes, the maximum accelerations were 186 and 438 gals on the ground surface, and 310 and 230 gals on the pier top, respectively. Analyses of frequency characteristics of the motions showed that the predominant frequencies of pier-foundation were always approximately identical with the fundamental natural frequency of the subsoil. Analyses of micro-tremors measured at the sites revealed that the natural frequency of the pier-foundation system is higher than the fundamental natural frequency of the subsoil. Analytical models were formulated to calculate the seismic response of the pier-foundation assuming the subsoil and pier-foundation to be a shear column model with an equivalent linear shear modulus and an elastically supported beam on the subsoil, respectively. Bedrock motions were computed from the measured ground surface motions and then applied to the bedrock of the analytical model. The seismic responses of pier-foundation were thus calculated and compared with the measured records giving a good agreement.